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KMID : 1137020200310060085
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Journal of Gynecologic Oncology
2020 Volume.31 No. 6 p.85 ~ p.85
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Feasibility and safety of fertility-sparing surgery in epithelial ovarian cancer with dense adhesion: a long-term result from a single institution
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Baek Min-Hyun
Park Jeong-Yeol
Kim Dae-Yeon
Suh Dae-Shik
Kim Jong-Hyeok
Kim Yong-Man
Kim Young-Tak
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Abstract
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Objective: We investigated the feasibility and safety of fertility-sparing surgery (FSS) in patients with epithelial ovarian cancer (EOC) with dense adhesions.
Methods: Patients were divided into cases with and without dense adhesions in this retrospective study.
Results: Of the 95 eligible patients, 29 patients had dense adhesions. Mean age, proportion of staging procedure, distribution of histologic type, and co-presence of endometriosis were different (p=0.003, 0.033, 0.011, and 0.011, respectively). The median follow-up period was 57.8 (0.4?230.0) months. There were no differences in the rates of recurrence (21.2% vs. 20.7%, p=1.000) or death (16.7% vs. 6.9%, p=0.332) between the 2 groups. There was no difference in the pattern of recurrence or in disease-free survival (DFS) and overall survival (OS) between the 2 groups. In multivariate analysis, pretreatment cancer antigen-125 >35 U/mL and International Federation of Gynecology and Obstetrics stage IC were significant factors of worse DFS and OS, while dense adhesion was not a prognostic factor for both DFS (hazard ratio [HR]=0.9; 95% confidence interval [CI]=0.3?2.7; p=0.792) and OS (HR=0.2; 95% CI=0.1?1.8; p=0.142), nor were age, proportion of staging procedure, histologic type, and co-presence of endometriosis. Moreover, the distribution of those 2 significant prognostic factors was not different between the 2 groups. Dense adhesions were subgrouped into non-tumor and tumor associated dense adhesions for further analysis and the results were same.
Conclusion: FSS is feasible and safe in EOC, regardless of the presence of dense adhesions.
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KEYWORD
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Tissue Adhesions, Ovarian Neoplasms, Fertility Preservation, Gynecologic Surgery
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